Disruption of the Notch pathway aggravates airway inflammation by inhibiting regulatory T cell differentiation via regulation of plasmacytoid dendritic cells
SY Qu, XY Ti, J Zhang, C Wu - Scandinavian Journal of …, 2020 - Wiley Online Library
Plasmacytoid dendritic cells (pDCs) regulate immunity and promote tolerance in asthma.
Notch signalling is a highly conserved pathway that regulates the immune response;
however, its role in pDC‐mediated asthmatic airway inflammation is unclear. This study
clarified the effects of Notch signalling on pDC‐mediated airway inflammation using murine
models of ovalbumin‐sensitized allergic asthma. RBP‐J‐deficient pDCs (RBP‐J−/− pDCs)
were co‐cultured with naïve CD4+ T cells and supernatants and T cell subtypes were …
Notch signalling is a highly conserved pathway that regulates the immune response;
however, its role in pDC‐mediated asthmatic airway inflammation is unclear. This study
clarified the effects of Notch signalling on pDC‐mediated airway inflammation using murine
models of ovalbumin‐sensitized allergic asthma. RBP‐J‐deficient pDCs (RBP‐J−/− pDCs)
were co‐cultured with naïve CD4+ T cells and supernatants and T cell subtypes were …
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